Dr Andrew Laslett

Team Leader

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Biography

Dr. Andrew Laslett is a Research Team Leader with the CSIRO Manufacturing business unit, where he leads a human pluripotent stem cell biology research team; He also holds an Adjunct Associate Professor position with the Australian Regenerative Medicine Institute at Monash University and is an Honorary Senior Fellow with the School of BioSciences at Melbourne University. Since 2001, Andrew and his laboratory have focused on elucidating the complex biology of human embryonic stem cells (hESC), examined methods for the differentiation of hESC to renal progenitor cells and more recently begun comparing hESC to reprogrammed human cells termed induced pluripotent stem (iPS) cells. His laboratory is currently focused on exploiting the basic biology of these cell types to create novel cell lines and tools that enhance human pluripotent cell research translation within CSIRO, Australia and internationally. Prior to his current role with CSIRO, Andrew was a Senior Scientist and Group Leader of the Human Embryonic Stem Cell Technology Laboratory at the Australian Stem Cell Centre (ASCC) following Senior Research Fellow appointments in the Laboratory of Embryonic Stem Cell Biology and the Centre for Reproduction and Development, Monash Institute of Medical Research, Monash University. He obtained his BSc (Hons) and PhD (1996) from Monash University prior to undertaking postdoctoral positions in both Hong Kong and Philadelphia, USA.

Other Interests

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Current Roles

  • Project Leader
    OD-201659 Unveiling Human Reprogramming

  • Project Leader
    OD-200522 MAB exploitation

  • Project Leader
    OD-17325 Inducing and Controlling PLuripotency

  • Project Leader
    OD-203871 Production of hiHeps for bioartificial livers using chemically defined substrates

  • Project Leader
    OD-201659 Unveiling human reprogramming

  • Project Leader
    OD-204102 Breast iPS cells

Academic Qualifications

  • 1996

    PhD
    Monash University

  • 1986


    Melbourne High School

  • 1991

    B. Sc. (Hons)
    Monash University

Professional Experiences

  • 2009-present

    Research Team and Project Leader
    CSIRO

  • 2013-present

    Adjunct Associate Professor
    Monash University

  • 2011-2014

    Research Group Leader
    CSIRO

  • 2006-2012

    Adjunct Senior Lecturer
    Monash University

  • 2006-2009

    Research Team Leader
    Australian Stem Cell Centre

  • 2005-2006

    Senior Research Fellow
    Monash University

Achievements and Awards

  • 2011-present

    Honorary Senior Fellow
    School of BioSciences, Melbourne University

  • 2007-2009

    Elected Board Member and Director
    Australian Society for Medical Research

Other highlights

  • 2016-present

    Seven monoclonal antibodies detecting cell surface proteins on undifferentiated human embryonic stem cells were licensed for worldwide distribution as research reagents by Thermo Fisher Scientific

Grants

  • 2017-2020

    CAS-CSIRO Project Fund. Production of hiHeps for bioartificial livers using chemically-defined substrates. Andrew Laslett (CSIRO) and Lijian Hui (SIBCB, CAS

  • 2017-2020

    CSIRO Postdoctoral Fellowship Funding Scheme: Development of a screening process for the identification of cancer prevention agents. Andrew Laslett, Jane Visvader (WEHI), Carmel O’Brien.

  • 2016-2019

    NHMRC Project grant: Unveiling the human reprogramming pathway. CIA Jose Polo, CIB Andrew Laslett

  • 2016-2019

    NHMRC Project grant: Using direct reprogramming to create and rejuvenate haematopoietic stem cells. CIA Jose Polo, CIB Susie Nilsson, CIC Owen Rackham AI Andrew Laslett

  • 2015-2017

    NHMRC Project grant: Inducing and controlling cellular plasticity. CIA Jose Polo, CIB Andrew Laslett, CIC Mirana Ramialison

  • 2014-2017

    CSIRO OCE Postdoctoral Fellowship Funding Scheme: Accelerating translation of cellular reprogramming through smart materials design Cooper-White, Laslett, Polo, Meagher, Esteban.

  • 2013-2013

    Stem Cells Australia Strategic Research Fund: Project number 2013F-9, “Identify additional novel and specific cell surface markers of human NC progenitors that can be used to isolate these cells by FACS”. Mirella Dottori with co-applicants Don Newgreen, Ben Rollo, Ernst Wolvetang, Justin Cooper-White, Christine Wells and Andrew Laslett.

  • 2012-2015

    CSIRO OCE Postdoctoral Fellowship Funding Scheme: Direct Reprogramming to Blood Stem Cells Laslett, Nilsson, Haylock.

  • 2012-2015

    CIRM-NHMRC collaborative grant: Multiple Sclerosis Therapy: Human Pluripotent Stem Cell-Derived Neural Progenitor Cells in partnership with researchers from UC Irvine (Prof. Tom Lane) & San Diego (Assoc. Prof. Louise Laurent) and Scripps Research Institute (Prof. Jeanne Loring), Monash University (Prof. Claude Bernard) and CSIRO Andrew Laslett and Carmel O’Brien).

  • 2011-2018

    ARC Special Research Initiative in Stem Cell Science, Stem Cells Australia. (University of Melbourne, Monash University, University of Queensland, University of New South Wales, Walter and Eliza Hall Institute & CSIRO, CIs Martin Pera, Trevor Kilpatrick, David Gardner, Doug Hilton, Nadia Rosenthal, Andrew Elefanty, Ed Stanley, Tiziano Barberi, Peter Gray, Melissa Little, Justin Cooper-White, Sean Grimmond, Ernst Wolvetang, Perry Bartlett, Christine Wells, Richard Harvey, Robert Graham. PIs, Warren Alexander, Andrew Laslett, Susie Nilsson, David Haylock). $21 million from ARC (no direct funds to CSIRO).

  • 2011-2016

    Science & Industry Endowment Fund. Understanding normal and aberrant stem cell biology to improve human health. Chief Investigators: Susie Nilsson, Andrew Laslett, David Haylock (CSIRO), Doug Hilton, Jane Visvader, Geoff Lindeman, Warren Alexander, Donald Metcalf (WEHI) and Andrew Nash (CSL) ($6 million).

  • 2010-2012

    NHMRC project grant. Generation of induced pluripotent stem (iPS) cells and their potential use in periodontal regeneration. Chief Investigators: Mark Bartold, Stan Gronthos, Peter Zilm, Andrew Laslett

  • 2009-2012

    CIRM / Victoria RFA08-05 Early Translational Research Award “Ensuring the safety of cell therapy: a quality control pipeline for cell purification and validation” Chief Investigators: Andrew L Laslett and Jeanne F. Loring (USD$932,000 to ALL and USD$3.051 million to JFL).

  • 2009-2011

    ASCC Collaborative streams, Development of Pluripotency Reporter Lines for Facile Screening of Bioreactor Conditions.

  • 2009-2011

    ASCC Collaborative streams, Are Human iPS Cells Equivalent to hESC?

  • 2009-2011

    ASCC Collaborative streams, Refining the Pluripotent Stem Cell Phenotype. ($280,000)

  • 2008-2010

    New Investigator NHMRC project grant “Generation of renal cells from human embryonic stem cells” $270,500

  • 2008-2010

    NSW/VIC Government Stem Cell Research Grant Program 2008, Reproducible production of patient-specific human embryonic like stem cell lines from somatic cell nuclear transfer (SCNT-hESC) and their characterisation and comparison to induced pluripotent cells (iPS) and conventional embryo-derived human embryonic stem cells (hESC) Lead Chief Investigators: Andrew L Laslett (ASCC) & Tomas Stojanov (SIVF), Other Investigators: Teija Peura, Naoki Nakayama, Jacqueline Rosains, Megan Munsie (ASCC), Julia Schaft, Omar Chami, David Lu, Michael Henman, Tammi Roy

  • 2007-2007

    2007 Kidney Health Australia seed grant, “Examining the renal potential of human embryonic stem cells: survival and integration studies using mouse embryonic kidney culture” $15,000

  • 2006-2009

    Australian Stem Cell Centre – Refining the human embryonic stem cell phenotype: Andrew Laslett

  • 2006-2006

    NHMRC large equipment grant ABI 7900 QPCR system Pritchard, Mansell, Hedger, Phillips, Wallace, Kitching, Hickey, Horne, Gargett, Laslett, Pera, Simpson, Fuller, Harley, Alderuccio, Loveland, Jans

  • 2004-2006

    Biotechnology Innovation Fund 2004-2006: Awarded to Nephrogenix Pty Ltd Project Title: Developing Cell based therapies for kidney disease. Project Number: BIF03275 Andrew Laslett, Martin Pera, Melissa Little , Andrew Perkins & John Bertram.

Community and Corporate Citizenship

  • 2015-present

    Appointed Chair of Biosafety committee (IBC#306) of the CSIRO Manufacturing

  • 2009-present

    Member editorial board Stem Cells

Publications

We have publications by Dr Andrew Laslett
For more publications, please see Google Scholar: E6qKxd4AAAAJ Researcher ID: A-9760-2011 ORCID: orcid.org/0000-0003-4729-8193