Contact details:
ADELAIDE SA 5000 AUSTRALIA
Biography
Ilka Priebe is an Experimental Scientist in the Diagnostics group at Kintore Ave. Adelaide, working in cell and protein biology. The area of research focuses on non-invasive biomarkers of healthy ageing and markers for the intestinal health and disease. Ilka has played a key role in developing blood-based protein biomarkers for the early detection of colorectal cancer. Ilka has extensive experience in biomarker analysis and validation and has strong skills in ELISA-based techniques, including cell based assays, cell culture and passage, processing of blood samples, Proteomics, SDS-PAGE, Western blotting, including hybridomas and operating of the fully automated TECAN liquid handling robot and the Luminex Liquichip platform.
Expertise and research focus:
• Establishing of gut organoids from human gut epithelium derived from normal and tumour/CRC patients as a high throughput screening platform to optimise therapeutic strategies.
•The identification of novel biomarkers for the detection and prevention of colorectal cancer.
•The development of a fully humanised antibody as a cancer therapeutic.
This project was a joint venture with CSIRO and DYAX , a Boston based USA company.
•Apoptosis and the Pharmacology of Butyrate:
establishing the Free Flow Electrophoresis system (FFE) and DIGE as a Proteomics platform which aims to further elucidate the mechanisms of butyrate action in susceptible cells and butyrate resistance in some tumor cells
•Involved in the characterisation of novel IGF-I analogues that modulate the outcomes from IGF receptor signalling, and to evaluate potential therapeutic applications
CONTRIBUTED TOWARDS PATENTS:
The most recent patent involves the identification and validation of biomarkers for a blood based assay for the diagnosis in Colorectal Cancer. Diagnostic for colorectal cancer. Cosgrove L J, Tabor B, Burgess A, Nice E.AU/2011/000895, WO2012/006681
PCT/AU01/00010.Growth Factor Splice Variant. Andrew J. Dunbar and Chris Goddard. (2001)
PCT/AU98/00942. (US Patent 06531134). Mammalian Milk Growth Factor. Andrew J. Dunbar, David A Belford, Chris Goddard. (1998).