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Prof Michelle Colgrave

Future Protein Lead

https://people.csiro.au/c/m/michelle-colgrave

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BIOSCIENCE PREC 306 CARMODY RD
ST. LUCIA QLD 4067 AUSTRALIA

Biography

Professor Michelle Colgrave is the Future Protein Lead in CSIRO Agriculture and Food, based at the Queensland Bioscience Precinct in Brisbane, Australia. Prof Michelle Colgrave is using mass spectrometry (MS) and proteomics to help identify key proteins that will benefit Australia's livestock and plant industries and improve human health. Proteomics is the study of proteins using mass spectrometry. Prof Colgrave is working to identify novel proteins and characterise their function and post-translational modifications. Prof Colgrave is a Chief Investigator on the ARC Centre of Excellence for Innovations in Peptide and Protein Science.

Prof Colgrave is using MS as a tool for:
(1) detection of differential protein and peptide expression, for example examining the change in expression of proteins under biotic or abiotic stress, or across diverse germplasm;
(2) characterisation of post-translational protein modifications such as glycosylationof viral proteins;
(3) peptide detection, sequence analysis and quantification with applications in food safety, e.g. the quantification of gluten proteins in food and beverages; and
(4) developing novel approaches and workflows for integrating multi-omic data.

Prior to joining CSIRO, Prof Michelle Colgrave has built strong, international reputation for her studies in the structure and function of bioactive peptides, namely the cyclotides. Her research, often applying innovative approaches, has been widely published in high impact journals (ACS Chemical Biology, Journal of Biological Chemistry, Biophysical Journal). Her findings have gone beyond reporting molecular structures to uncovering the evolution and development of these peptides (PNAS, Nature Chemical Biology, Plant Cell). She is the editor of the book “Proteomics in Food Science: From Farm to Fork” aimed at introducing the application of MS and proteomics to the food science and agricultural research communities.

Since joining CSIRO in 2007, she has applied proteomic approaches to diverse biological systems, ensuring the success of projects as well as production of high quality publications (PNAS, Molecular Endocrinology, PLoS ONE, Journal of Proteome Research, Proteomics, Biochemistry). Since 2010 Prof Colgrave has applied MS techniques for the quantification of gluten (hordeins in barley; gliadins and glutenins in wheat). The success of this research has been recognized by receipt of the ICM Agrifood Award (Australian Academy of Technology and Engineering (ATSE) Innovation and Excellence Awards, 2020), CSIRO Chairman's Medal (2016), Plant Industry Research Achievement Award (2014), the Payne-Scott Award (2014) and the John Philip Award for Promotion of Excellence in Young Scientists (2012).

Professional Areas

Fields of Research

Current

Current Roles

  • Principal Research Scientist
    Proteomics

  • Lead
    Future Protein

Academic Qualifications

  • 2002

    PhD
    University of Wollongong

  • 1999

    B Adv Sci (Hons I)
    University of Wollongong

Professional Experiences

  • 2007-2019

    Proteomics Research Scientist
    CSIRO

  • 2006-2007

    Field Application Scientist
    Applied Biosystems

  • 2002-2006

    Senior Research Officer
    Institute for Molecular Bioscience, University of Queensland

  • 2001-2002

    Research Fellow
    Nottingham Trent University

Achievements and Awards

  • 2020-2020

    ICM Agrifood Award
    Australian Academy of Technology and Engineering (ATSE)

  • 2017-2017

    Runner-up “Women in Research Award”, Scopus Researcher Awards
    Elsevier

  • 2017-2017

    Agriculture & Food Director’s Award for Leadership
    CSIRO

  • 2016-2016

    Chairman's Medal
    CSIRO

  • 2014-2016

    Payne-Scott Award
    CSIRO

  • 2014-2014

    Plant Industry Research Achievement Award
    CSIRO

  • 2012-2013

    John Philip Award for the Promotion of Excellence in Young Scientists
    CSIRO

  • 2012-2012

    CSIRO Research Achievement Award (Resilin)
    CSIRO

  • 2008-2011

    Julius Career Award
    CSIRO

Community and Corporate Citizenship

  • 2020-2023

    Asia Oceania Agricultural Proteomics Organization (AOAPO) Board Member

  • 2020-2021

    AgCatalyst (CSIRO) Steering Committee

  • 2016-2020

    Australasian Proteomics Society (APS) Board Member

  • 2017-2019

    HUPO 2019 Organising Committee

  • 2018-2018

    AgCatalyst (CSIRO) Steering Committee

  • 2014-2015

    ANZSMS15 Conference Organising Committee

  • 2012-2018

    Editorial Board Member: Peptidomics

  • 2011-2018

    Editorial Board Member: Journal of Integrated Omics

  • 2010-2015

    Education & Training Officer, APS

Related links

Publications

We have publications by Prof Michelle Colgrave